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KMID : 0811820110150020146
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Journal of Korean Society of Pediatric Nephrology
2011 Volume.15 No. 2 p.146 ~ p.153
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Urinary Calcium Excretion in Children with Primary Monosymptomatic Nocturnal Enuresis
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Chung Woo-Yeong
Cho Min-Hyun
Park Yong-Hoon
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Abstract
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Purpose: Hypercalciuria has been suggested to be involved in the pathogenesis of nocturnal enuresis associated with polyuria. We have measured the amount of calcium excretion in the urine from children with monosymptomatic nocturnal enuresis and studied the association with enuresis.
Methods: Thirty-six children (20 males and 16 females, age 5 to 15.6 years) presenting with monosymptomatic nocturnal enuresis were recruited for this study.
Results: Among 36 patients, 6 patients had hypercalciuria, providing a 16.7% frequency. The mean Ca/Cr ratio of hypercalciuria group showed on daytime, and on nighttime showing higher values in nighttime, but it was not statistically significant. Average 24 hour calcium excretion was 8.95 mg/kg. Night/day time urine volume ratio in hypercalciuria group was , and that in normocalciuria group was , also showing no difference. Daytime Ca/Cr ratio and nighttime Ca/Cr ratio from all enuresis patients showed a significant correlation (P=0.0001). However, Ca/Cr ratio between daytime and nighttime urine volume had no significant correlation, respectively (daytime P=0.08; nighttime P=0.07). Also, daytime and nighttime Na concentration, urea concentration, and osmolality also had no significant correlation with urine Ca/Cr ratio, respectively.
Conslusion: Hypercalciuria shown in some of enuresis patients is not directly caused by primary monosymptomatic nocturnal enuresis.
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KEYWORD
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Children, Primary monosymptomatic nocturnal enuresis, Hypercalciuria
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